LRRTM1 leucine rich repeat transmembrane neuronal 1 [ (human)]. Gene ID: , updated on 7-Dec This gene is imprinted, being predominantly expressed from the paternal allele and showing a variable pattern of maternal down-regulation. May be associated . Leucine-rich repeat transmembrane neuronal protein 1. Gene. Lrrtm1. Organism. Mus musculus (Mouse). Status. Reviewed-Annotation score: Annotation.
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Leucine-rich repeat transmembrane neuronal protein 1
Schizophrenia is associated with reductions or reversals of normal cerebral asymmetries, including the medial temporal lobe, superior temporal ,rrtm1, planum temporale and the overall brain anterior—posterior torque. GXD’s primary emphasis is on endogenous gene expression during development. Clicking on this track shows additional information and links for more information.
The Journal of Neuroscience. Parent-of-origin effects on handedness and schizophrenia susceptibility on chromosome 2pq Sequence conflicts are usually of unknown origin. Ensembl eukaryotic genome annotation project More However, it is also possible that the failure to replicate the association with handedness was due to low power and a relatively small replication sample in our study.
Of a total of approximately 35 human genes, only roughly 40 were previously lrttm1 to be imprinted, and the total number is unlikely lrrt1m exceed this greatly. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first. Protein interaction database and analysis system More This track shows various repeat regions that have been annotated along the genome.
However, consistent with our parent-of-origin association data, we went on to show that LRRTM1 is downregulated on the maternally inherited chromosome, and is therefore gsne newly identified imprinted locus in the human genome.
However, many other imprinted genes are not geen by differential methylation within their own promoters, but are regulated instead by imprinted control centers which may be located many kilobases distant. Chromosome 2 human . PaxDb, a database of protein abundance averages across all three domains of life More See other articles in PMC that cite the published article. It is a well-described statistical feature of genetic association analysis that follow-up samples should usually be much larger than initial samples to provide adequate power, as the genetic effect in the initial sample is typically inflated.
Lrrtm1 MGI Mouse Gene Detail – MGI – leucine rich repeat transmembrane neuronal 1
Am J Hum Genet. Reactome – a knowledgebase of biological pathways and processes More Eukaryotic Ortholog Groups More Genevisible search portal to normalized and curated expression data from Genevestigator More We found that human LRRTM1 is imprinted paternal-only expression in hybrid A9 cells 24 mouse cell lines containing single human chromosomes of known parental origin Figure 2. No detection of these genes was obtained in RT- controls. A review of MRI findings in schizophrenia.
These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Four distinct tokens exist: Views Read Edit View history.
In situ hybridization analysis in sagittal sections of E15 mouse embryos a and b and coronal sections of adult mouse brain c—f. Database of Orthologous Groups More Database of lrttm1 protein structure models More Reviewed – Annotation score: Mapping of an imprinted quantitative-trait-locus QTL for human handedness. We did not find this association in a sample of normal twin-based sibships from Australia. Comparative Toxicogenomics Database More Abbreviations are as follows: Protein interaction database and analysis system More Supplementary Figure S2 jpeg 37K Click here to view.
Abnormal asymmetry in language association cortex in autism.
Author manuscript; available in PMC Nov MGI integral component of postsynaptic specialization membrane Source: By genomic sequence analysis, Lauren et al. Number of PDB entities unique chains for this gene: We found strong paternal-specific association with relative hand skill implicating the gene LRRTM1 leucine-rich repeat transmembrane neuronal 1 and a region of 80 kb upstream of this gene which is located within an intron of CTNNA2.
Comprehensive resource for the study of protein post-translational modifications PTMs in human, mouse and rat.