In cases of acute intoxication with propane butane (due to damage in heating appliances where propane-butane is used as energy source for heating), asphyxia. Butane is an organic compound with the formula C4H10 that is an alkane with four carbon . It enters the blood supply and within seconds produces intoxication. Butane is the most commonly misused volatile substance in the UK, and was the. Butane is a commonly misused volatile agent, and a cause of intoxication. We present a case, who had a syncope and persistent ventricular.
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The AEGL-3 values are greater than the lower explosive limit for butane in air of 19, ppm. These data are only briefly described because they provide no clear dose-response data and, for abuse cases, subjects generally have a history of repeated exposure, so tolerance to butane could have developed Evans and Raistrick Concerned parents Children affected by a parent’s drinking Alcohol and Bjtane Worried about someone? However, the experimental procedure is poorly described but suggests that reported concentrations are probably initial concentrations in a closed-chamber setting.
The toxicity of butane is low. Phenomenology of intoxication with toluene-based adhesives and butane gas; pp.
Deaths occurred after 84 min on average at an initial butane concentration ofppm and after 65 min on average at an initial concentration ofppm. A summary of data on lethality from acute inhalation of butane is provided in Table None, Conflict of Interest: Users may maintain the high by continuing to inhale the fumes. Because the study by Shugaev reports only LC 16 intoxicstion, LC 50and the LC 84 values obtained by probit analysis and not the individual experimental data, benchmark dose-response modeling is not possible.
All deaths occurred during exposure. Total uncertainty factor of 3 for differences between species and individuals.
Myocardial contractility the rate of rise in left ventricular pressure and mean aortic pressure showed a concentration-related decrease starting at 25, ppm. Butane at concentrations ofandppm caused mortality see Section 3. GABA A receptor positive modulators. Thirteen of these cases were associated with butane Bowen et al.
Individual scores did not differ much from the average scores. Second, intoxicafion noticeable irritation was reported at concentrations up toppm for a short duration exact duration unknown. A forensic analysis and immunohistochemical detection of myocardial hypoxic damage. Patty and Yant studied the warning properties of several alkanes, including butane.
Other dogs showed no ventricular fibrillation after injection with epinephrine when exposed to butane at about 50, ppm. In nonfatal cases, butane appears to have frequently buutane the heart and brain. Case studies also reveal that serious brain damage and underdeveloped organs can occur in fetuses in case of high single exposures during the week 27 or 30 of pregnancy.
Retrieved 11 December Propane and isobutane were also detected. Other viscera were reported to be unremarkable.
Rhabdomyolyse aiguë lors d’une intoxication au butane. À propos de deux cas – EM|consulte
She gradually regained consciousness and was discharged 48 h after admission. Ifkharen aM. The concentration-response curve was very steep, with LC No noticeable irritation was reported at concentrations up toppm for a short but undefined exposure period; the odor detection score was below 4 cogent, forcible odor.
Each dog was exposed butane at nominal concentrations of 0. Hence, this study does not provide an adequate starting point for deriving AEGL-3 values.
The results of the key study in mice are comparable with the results from a second study in mice. Butane used in gas lighter refills consists of butane with small amounts of isobutane and propane.
LC 16 ratios of approximately 1.
Butane intoxication–three case reports.
You may butand request that your data, should it be inaccurate, incomplete, unclear, outdated, not be used or stored, be corrected, clarified, updated or deleted. Access to the text HTML. In the case of butane abuse, most of the health effects described in case reports are thought to be induced by repeated exposures and abuse of other chemicals cannot be ruled out.
When blended with propane and intkxication hydrocarbons, it may be referred to commercially as LPGfor liquefied petroleum gas. Also, no noticeable irritation was reported at concentrations up toppm probably for a few minand a larger uncertainty factor of 3 would lead to unrealistically low AEGL-1 values.
After a steady state has been reached, no increase in effect severity by exposure duration is expected. Most of the mice died during the second hour of exposure. Support Center Support Center.
Butane is a colorless gas with a faint disagreeable odor, although it bjtane considered to be odorless by some. Nuckolls exposed groups of three guinea pigs for 5, 30, 60, or min to 50, ppm for 2 h. Derivation of AEGL-2 Case reports indicate that single exposure to intoxicatioon concentrations of butane might cause severe brain damage in the fetus, but no adequate human or animal data are available for a quantitative evaluation of this end point.
Fatal poisoning by butane sniffing: